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49ers @ Cards

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The Cardinals won 28-18 in Santa Clara in Week 5, extending their win streak over the 49ers to seven games. Their longest win streak over any opponent since relocating to Arizona is eight straight wins over the Rams from 2006 through 2010.

The 49ers fell to the Rams, 39-10, their fifth straight loss and second-largest home loss of the decade (40-10 to Dallas in Week 7 last season). The 49ers have lost their first four road games of the season. They have lost their first five road games in each season of the post-Jim Harbaugh era (since 2015).

The Cardinals lost to Denver, 45-10, last Thursday. That was Arizona's second loss this season by more than 30 points. The Cardinals have failed to gather 300 total yards in 11 straight games, the longest streak in the NFL since the Texans in 2004 and 2005.

George Kittle had 98 receiving yards and a touchdown in the loss to the Rams. Kittle has 29.6 percent of the 49ers' receiving yards (527/1780), second-highest percentage by any tight end this season (Zach Ertz -- 31.4 percent).

Larry Fitzgerald hauled in his first touchdown of the season against Denver. It was the 111th of his career, tying him with Tony Gonzalez for seventh most all-time. Fitzgerald has 17 career receiving touchdowns against San Francisco, the most by any player all-time against the 49ers.

San Francisco boasts the league's second-best rushing attack this season, averaging 137.4 yards on the ground. Arizona has the league's worst rush defense, allowing 148.3 yards per game. The 49ers rushed for 147 yards against the Cardinals in their first meeting this season.


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